The African turquoise killifish: A research organism to study vertebrate aging and diapause
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چکیده
منابع مشابه
The African turquoise killifish: A research organism to study vertebrate aging and diapause.
The African turquoise killifish has recently gained significant traction as a new research organism in the aging field. Our understanding of aging has strongly benefited from canonical research organisms-yeast, C. elegans, Drosophila, zebrafish, and mice. Many characteristics that are essential to understand aging-for example, the adaptive immune system or the hypothalamo-pituitary axis-are onl...
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Why and how organisms age remains a mystery, and it defines one of the biggest challenges in biology. Aging is also the primary risk factor for many human pathologies, such as cancer, diabetes, cardiovascular diseases, and neurodegenerative diseases. Thus, manipulating the aging rate and potentially postponing the onset of these devastating diseases could have a tremendous impact on human healt...
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Reichard et al. introduce the turquoise killifish (Nothobranchius furzeri), notable for its short-life span and diapause stage.
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The African killifish Nothobranchius furzeri is the shortest-lived vertebrate that can be bred in captivity. N. furzeri comprises several wild-derived strains with striking differences in longevity ranging from 3 to 9 months, which makes it a powerful vertebrate model for aging research. The short life cycle of N. furzeri should also facilitate studies on adult traits that are specific to verte...
متن کاملThe African Turquoise Killifish Genome Provides Insights into Evolution and Genetic Architecture of Lifespan
Lifespan is a remarkably diverse trait ranging from a few days to several hundred years in nature, but the mechanisms underlying the evolution of lifespan differences remain elusive. Here we de novo assemble a reference genome for the naturally short-lived African turquoise killifish, providing a unique resource for comparative and experimental genomics. The identification of genes under positi...
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ژورنال
عنوان ژورنال: Aging Cell
سال: 2018
ISSN: 1474-9718
DOI: 10.1111/acel.12757